The very nature of depression interferes with a person's ability to seek help, draining energy and self-esteem. Those who suffer from dysthymia are usually able to function normally, but seem consistently unhappy. To learn more about participating in a clinical trial, please visit www. Talk to a representative Email: There are several different types or subtypes of depression , including:. It is more than just "the winter blues" or "cabin fever. ECT can be safe and highly effective for severe, treatment-resistant depression, as well as a variety of other serious mental disorders.